hTIM3

品系全名

C57BL/6JSmo-Havcr2tm1(hHAVCR2)/Smoc

目录号

NM-HU-00054

品系状态

胚胎冻存

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基因信息

基因名
Havcr2

品系描述

通过同源重组,将小鼠Tim3基因进行人源化修饰。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

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Fig1. Detection of TIM3 expression by PCR. 

Wild type: only one band at 248 bp with primers F2/R2(mTim3);

Homozygous: only one band at 328 bp with primers F1/R1(hTIM3); 

Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png Fig2. Analysis of hTIM3 expression on stimulated CD4+ and CD8+  T cells in hTIM-3 knockin mice by FACS. (Completed in cooperation with CrownBio)


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Fig3. Analysis of hTIM3 expression at very low levels on naive T cells by FACS.

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Fig4. Analysis of hTIM3 expression at high levels on CD11b+ myeloid cells by FACS.


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