hCRLF2

品系全名

C57BL/6JSmo-Crlf2tm1(hCRLF2)Smoc

目录号

NM-HU-210028

品系状态

胚胎冻存

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基因信息

基因名
Crlf2

品系描述

利用ES细胞打靶方式,将小鼠Crlf2基因全部或者部分替换为人源CRLF2。从而表达人或人鼠嵌合CRLF2蛋白,取代小鼠内源Crlf2蛋白的表达。
应用领域:免疫治疗;药物筛选

验证数据

image.png

Fig.1 Detection of hCRLF2 expression in the bone marrow of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.2 Detection of hCRLF2 expression in the blood of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hCRLF2 expression in the spleen of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of mCRLF2 expression in the bone marrow of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of mCRLF2 expression in the blood of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of mCRLF2 expression in the spleen of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.


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