hIL1B

品系全名

C57BL/6JSmo-Il1btm3(hIL1B)Smoc

目录号

NM-HU-190047

品系状态

活体

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基因信息

基因名
IL1B

品系描述

通过同源重组,将小鼠基因Il1b进行人源化修饰。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

huIL1b.png


图1. Elisa检测IL1B人源化纯合子(HO)小鼠中人源IL1b的表达。 使用LPS刺激3h后,摘眼球取血清进行Elisa检测,结果显示IL1B人源化纯合子小鼠中人源IL1B表达活跃,符合预期。

mIL1b.png

图2 Elisa检测IL1B人源化杂合子(HO)小鼠中鼠源IL1B的表达。使用LPS刺激3h后,摘眼球取血清进行Elisa检测,结果显示WT小鼠鼠源IL1B表达活跃,HO小鼠无鼠源IL1B表达,符合预期。


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