hSIGLEC15

品系全名

C57BL/6JSmo-Siglec15tm1(hSIGLEC15)Smoc

目录号

NM-HU-190037

品系状态

胚胎冻存

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基因信息

基因名
SIGLEC15

品系描述

通过同源重组,将小鼠Siglec15基因进行人源化修饰。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据


SIGLEC15-HU-1.pngSIGLEC15-HU-2.png

Fig1. SIGLEC15 人源化小鼠模型抗 SIGLEC15 人源化抗体 5G12-hIgG1 体内抗肿瘤效果 。SIGLEC15 抗体 5G12-hIgG1 能够显著抑制 MC38 肿瘤在 SIGLEC15 人源化小鼠体内的生长,证明 SIGLEC15 人源化小鼠可用于评估 anti-human SIGLEC15 antibody。(与Crownbio合作完成)


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