hSTING

品系全名

C57BL/6JSmo-Tmem173tm2(hTMEM173)Smoc

目录号

NM-HU-190036

品系状态

胚胎冻存

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品系描述

通过同源重组,将小鼠Tmem173基因进行人源化修饰。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

sting-cd4.png

图1 FACS检测STING人源化小鼠CD4+T细胞中人源STING的表达。结果显示:STING人源化杂合子小鼠外周血、脾脏、胸腺及淋巴结的CD4+T细胞中人源STING表达活跃。


sting-cd8.png

图2 FACS检测STING人源化小鼠CD8+T细胞中人源STING的表达。结果显示:STING人源化杂合子小鼠外周血、脾脏、胸腺及淋巴结CD8T细胞中人源STING表达活跃。


sting-3.png

图3 FACS检测STING人源化小鼠心脏和肺中人源STING的表达。结果显示:STING人源化杂合子小鼠心脏和肺中人源STING表达活跃。


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