R26-pAPOE-hCYP3A4(FVB)

品系全名

FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)Smoc

目录号

NM-KI-18032

品系状态

胚胎冻存

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基因信息

基因名
Gt(ROSA)26Sor

品系描述

该基因敲入模型是将肝脏特异性APOE启动子驱动的人源CYP3A4 cDNA插入到Rosa26位点中,该模型可与Cyp3a13基因以及其它Cyp3a家族基因簇敲除小鼠交配后获得肝脏表达的CYP3A4人源化小鼠模型,可与具有人CYP3A4的肠特异性表达的NM-KI-18033小鼠一起使用,以比较肠与肝代谢对测试物的生物转化的贡献。
应用领域:代谢

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