hICOS/hICOSL

品系全名

C57BL/6JSmo-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc

目录号

NM-HU-18018

品系状态

活体

导出PDF

品系描述

通过将hICOS和hICOSL小鼠交配获得该ICOS和ICOSL双人源化小鼠模型。 这些双重人源化小鼠模型可用于评估潜在免疫治疗药物组合的功效。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

image.png

Fig1. Detection of hICOSL expression on activated APCs in hICOSL KI mice and hICOS/hICOSL dKI mice. 

Note. The splenocyte-derived activated APCs were stimulated by LPS in vitro.

image.png

Fig2. Detection of hICOS expression on splenocyte-derived activated T cells in hICOS/hICOSL dKI mice.



你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看