hVSIG4

品系全名

C57BL/6JSmo-Vsig4tm1(hVSIG4)/Smoc

目录号

NM-HU-210004

品系状态

胚胎冻存

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基因信息

基因名
Vsig4

品系描述

通过同源重组,将小鼠Vsig4基因进行人源化修饰。
应用领域:免疫治疗;药物筛选

验证数据

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Fig1. Analysis of human VSIG4 expression on the peritoneal exudate macrophages by FACS. 

The homozygous KI mouse expresses human VSIG4 on the peritoneal exudate macrophages.

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Fig.2 In vivo efficacy assessment of anti-hVSIG4 in HO hVSIG4 mice bearing MC38 syngeneic tumor.

Body weight were measured twice a week of hVSIG4 mice (n=4 , 3 male and 1 female). (A) Body weight. (B) Body weight change.

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Fig.3 In vivo efficacy assessment of anti-hVSIG4 in HO hVSIG4 mice bearing MC38 syngeneic tumor.

Tumor volume were measured twice a week of hVSIG4 mice. MC38 (1×106) were inoculated subcutaneously into hVSIG4 mice (6-8-week-old, n=4, 3 male and 1 female). (A) Tumor volume. (B) Relative tumor volume.


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