hPD-1/hPD-L1
品系全名
C57BL/6JSmo-Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Smoc
目录号
NM-HU-00100
品系状态
活体
品系描述
验证数据
图1 FACS 检测 PD-1&PD-L1 双人源化纯合子小鼠人源 PD-1 和 PD-L1 的表达。
结果显示在 PD-1&PD-L1 双人源化纯合子小鼠可以检测到人源 PD-1 和 PD-L1 的表达。
药效验证数据
图2 PD-1&PD-L1 双人源化小鼠 MC38 荷瘤模型体内抗肿瘤药效验证。PD-1&PD-L1 双人源化纯合子小鼠接种 MC38细胞，肿瘤生长至约 100 mm3 时，随机将动物分组为对照组和不同组合的治疗组（n=8）。
结果显示：针对人的 PD-1 抗体和 PD-L1 抗体联合使用，与单独治疗组相比，有非常显著的抗肿瘤效果，证明 PD-1&PD-L1 双人源化小鼠是一个很好的验证针对人 PD-1&PD-L1 抗体联合药效的体内模型。
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