hPD-L1/hCTLA-4
品系全名
C57BL/6JSmo-Ctla4tm1(hCTLA4)Cd274tm1(hPD-L1)Smoc
目录号
NM-HU-00102
品系状态
胚胎冻存
品系描述
验证数据
图1 FACS检测PD-L1&CTLA4双人源化小鼠CD3+T细胞中人源PD-L1&CTLA4的表达。结果显示：PDL1/CTLA4双人源化纯合子小鼠通过尾静脉注射刀豆蛋白（12mg/kg）刺激4h，取脾脏细胞进行流式验证。PD-L1&CTLA4人源化纯合子小鼠脾脏的CD3+T细胞中人源PD-L1和CTLA4都表达活跃，且都无鼠源PD-L1和CTLA4表达。
图2. hCTLA4&PD-L1双人源化小鼠MC38 荷瘤模型体内抗肿瘤药效验证。 hCTLA4&PD-L1双人源化纯合子小鼠接种MC38 结肠癌细胞系，给药后结果显示：针对人的CTLA4&PD-L1双靶点联合用药相对于单药来讲显示出更加显著的抗肿瘤效果。
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