hCTLA-4
品系全名
C57BL/6Smoc-Ctla4tm1(hCTLA4) Smoc
目录号
NM-HU-00014
品系状态
活体
基因信息
基因名
CTLA4
品系描述
验证数据
CTLA4人源化小鼠流式分析（FACS）数据
图1. FACS 检测CTLA4 人源化小鼠活化后脾脏淋巴细胞的CTLA4 表达。CTLA4 人源化纯合子小鼠脾脏淋巴细胞经anti-CD3 和anti-CD28刺激 72h 后收集细胞染色，FACS 检测人源CTLA4 表达。结果显示：CTLA4 人源化纯合子小鼠活化的CD4+ 和CD8+ T 淋巴细胞中可以检测到人源CTLA4 的活跃表达。（与CrownBio 合作完成）
CTLA4人源化小鼠MC38荷瘤模型体内验证结果
图2. CTLA4人源化小鼠模型的抗CTLA4人源化抗体Ipilimumab 体内抗肿瘤效果
CTLA4 人源化小鼠 MC38 荷瘤模型体内抗肿瘤药效验证。CTLA4 人源化纯合子小鼠接种 MC38 结肠癌细胞系，结果显示： 针对人的 CTLA4 阳性药物 Yervoy 有非常显著的抗肿瘤效果（p<0.001），证明CTLA4 人源化小鼠是一个很好的验证针对人 CTLA4 抗体药效的体内模型。
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