hCD19/hCD3E

品系全名

C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc

目录号

NM-HU-190027

品系状态

胚胎冻存

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品系描述

通过将hCD19和hCD3E小鼠交配获得该CD19和CD3E双人源化小鼠模型。双重人源化小鼠模型可用于评估潜在免疫治疗药物组合的功效。
应用领域：免疫治疗；肿瘤研究；药物筛选

验证数据

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Fig1. Detection of CD19 expression in spleen by RT-PCR. Wild type: only one band at 368 bp with primers F1/R1(mCd19);Homoygous: only one band at 334 bp with primers F2/R2(hCD19); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of CD3E expression in spleen by RT-PCR. Wild type: only one band at 465 bp with primers F1/R1(mCd3e);Homoygous: one band at 516 bp with primers F1/R1(recombinant hCD3E) and one band at 349 bp with primers F2/R2(hCD3E); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig3. Immunotype in blood in hCD19/hCD3E mice 

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Fig4. Immunotype in blood in hCD19/hCD3E mice 

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Fig5. Immunotype in spleen in hCD19/hCD3E mice 

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Fig6. Immunotype in bone marrow in hCD19/hCD3E mice 

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