hIL22

品系全名

C57BL/6JSmo-Il22em(hIL22)Smoc

目录号

NM-HU-220419

品系状态

胚胎冻存

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基因信息

基因名
Il22

品系描述

利用同源重组,将小鼠Il22 基因进行人源化修饰。该品系上架销售日期为2026年2月25日。

验证数据

image.png

Fig.1 Detection of IL22 expression in cerebellum by RT-PCR. 

Wild type: only one band at 486 bp with primers F1/R1(mIl22);

Homozygous: only one band at 356 bp with primers F2/R2(hIL22).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig. 2 Detection of human IL22 expression(A) and mouse IL22(B)  in serum by ELISA. (n=3 for both groups )

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.

Note. The hIL22 and C57BL/6 mice were i.p. injected with LPS for 6h. The mouse IL22 ELISA kit cross-reacted with mIL22 and humanized IL22.


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