Slc32a1-IRES-Cre

品系全名

C57BL/6JSmo-Slc32a1em1(IRES-iCre)Smoc

目录号

NM-KI-200081

品系状态

活体

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基因信息

基因名
Slc32a1

基因曾用名

VGAT; Viaat; R75019

NCBI ID

22348

MGI ID

1194488

Ensembl ID

ENSMUSG00000037771

Pubmed

Slc32a1

人类同源基因

SLC32A1

品系描述

将IRES-iCre插入到小鼠Slc32a1基因终止密码子处。
应用领域：Cre工具鼠，Slc32a1是GABA 囊泡转运蛋白家族成员 1。Slc32a1-IRES-Cre与含有 loxP 侧翼序列的小鼠交配时，Cre 介导的重组将导致后代 GABA 能神经元中 floxed 序列的缺失。这些小鼠可用于研究 GABA 能神经元功能。

验证数据

image.png

图 1 Slc32a1Cre/+; Rosa26tdTomato/+小鼠脑中tdTomato的表达情况。

Slc32a1Cre/+; Rosa26tdTomato/+双转基因鼠，可在小鼠皮层、海马、下丘脑和小脑中检测到tdTomato的表达。

image.png

图 2 Slc32a1Cre/+; Rosa26tdTomato/+小鼠各组织中tdTomato的表达情况。TdTomato的表达可在皮层、海马、下丘脑和小脑、视网膜神经节细胞层、内网层和内核层中检测到。个别细胞表达的组织有：唾液腺、肾脏、胰腺、大肠、脾脏、胸腺、睾丸和附睾。不表达的组织有：心脏、肺、肝、小肠、表皮。（更多详细信息请联系我司技术顾问。）


发表文献 2篇

1. SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice
发表年份：2025 来源杂志：Nature Communications

2. Activation of noradrenergic terminals in the reticular thalamus delays arousal from propofol anesthesia in mice
发表年份：2019 来源杂志：FASEB JOURNAL

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