Thy1-CreERT2
品系全名
C57BL/6Smoc-Thy1em1(Kozak-CreERT2-WPRE-pA)Smoc
目录号
NM-KI-231054
品系状态
精子冻存
基因信息
基因名
Thy1
品系描述
将Kozak-CreERT2-WPRE-pA插入到小鼠Thy1基因起始密码子处。
*使用本品系发表的文献需注明: Thy1-CreERT2 mice (Cat. NO. NM-KI-231054) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Detection of tdTomato expression on CD90+ cells in BM, spleen and blood.
In tamoxifen-treated HE/HE Thy1-CreERT2/R26-CAG-LSL-tdTomato mice, most CD90+ cells were tdTomato+ in bone marrow (~70 %), spleen (~90 %) and blood (~95 %).
Fig2. Detection of CD90 expression on tdTomato+ cells in BM, spleen and blood.
In HE/HE Thy1-CreERT2/R26-CAG-LSL-tdTomato mice, most tdTomato+ cells were CD90+ in bone marrow (~60 %), spleen (~90 %) and blood (66.5~89.4 %).
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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