Ins2-CreERT2
品系全名
C57BL/6Smoc-Ins2em(CreERT2)1Smoc
目录号
NM-KI-225022
品系状态
活体
基因信息
基因名
Ins2
品系描述
将CreERT2插入到小鼠Ins2基因起始密码子处。
*使用本品系发表的文献需注明: Ins2-CreERT2 mice (Cat. NO. NM-KI-225022) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig 1. CreERT2-mediated recombination in pancreas of Ins2CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato(red) in various tissues of Ins2CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: pancreas, brain(choroid plexus). A few cells expressed in lung, stomach, small intestine, testis, thymus. Tissues that unexpressed include spinal cord, retina, liver, heart, salivary glands, brown fat, adrenal gland, kidneys, colon, spleen, muscle, skin. (7.3-week old, male) (For more detailed information please contact our technical advisor.)
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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