Avil-2A-CreERT2
品系全名
C57BL/6JSmoc-Avilem1(2A-CreERT2)Smoc
目录号
NM-KI-215035
品系状态
活体
基因信息
基因名
Avil
品系描述
将2A-CreERT2插入到小鼠Avil基因终止密码子处。
验证数据
Fig1. Avil-CreERT2/CAG-LSL-tdTomato mice were injected intraperitoneally with tamoxifen at a dose of 120 mg/kg, administered 3 times, every other day. Seven days after the last injection, the trigeminal ganglia of mice were harvested, the tdTomato signal was detected after tissue sectioning, and the NeuN signal was detected by immunofluorescence.
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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