Tlr5-CreERT2
品系全名
C57BL/6Smoc-Tlr5em1(CreERT2)Smoc
目录号
NM-KI-215033
品系状态
精子冻存
基因信息
基因名
Avil
品系描述
将CreERT2插入到小鼠Tlr5基因终止密码子处。
*使用本品系发表的文献需注明: Tlr5-CreERT2 mice (Cat. NO. NM-KI-215033) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Tlr5-CreERT2/CAG-LSL-tdTomato mice were injected intraperitoneally with tamoxifen at a dose of 120 mg/kg, administered 3 times, every other day. Seven days after the last injection, the Dorsal Root Ganglion (DRG) of mice were harvested, the tdTomato signal was detected after tissue sectioning.
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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