Dicer1-Flox

品系全名

C57BL/6JSmo-Dicer1em1(flox)Smoc

目录号

NM-CKO-200158

品系状态

活体

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基因信息

基因名
Dicer1

基因曾用名

D12Ertd7e; mKIAA0928; 1110006F08Rik

NCBI ID

192119

MGI ID

2177178

Ensembl ID

ENSMUSG00000041415

Pubmed

Dicer1

人类同源基因

DICER1

品系描述

在Dicer1基因exon 23两侧分别插入loxP位点，建立Dicer1基因条件性敲除小鼠模型。
应用领域：缺氧介导的EMT，茎干和基因表达相关研究

疾病预测

扩张型心肌病
Dilated Cardiomyopathy

近似模型的表型

MGI:5906349
注：该品系与Myh6-cre工具鼠交配才可能获得预期表型

参考文献

Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6

鳞状细胞癌
Squamous Cell Carcinoma

近似模型的表型

MGI:5618123
注：该品系与P53-Flox(2)(NM-CKO-190067)和KRT5-cre/PGR工具鼠交配才可能获得预期表型

参考文献

Lyle S, Hoover K, Colpan C, Zhu Z, Matijasevic Z, Jones SN, Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice. PLoS One. 2014;9(6):e100920

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5704363
注：该品系与Pten-Flox(NM-CKO-18004)和Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM, High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3921-6

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5704370
注：该品系与Pten-Flox(NM-CKO-18004)，P53-Flox(2)(NM-CKO-190067)和Amhr2-Cre工具鼠交配才可能获得预期表型

参考文献

Kim J, Coffey DM, Ma L, Matzuk MM, The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun;156(6):1975-81

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