Sidt2-Flox

品系全名

B6;129S-Sidt2tm1(flox)Smoc

目录号

NM-CKO-00041

品系状态

胚胎冻存

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基因信息

基因名
Sidt2

品系描述

loxp位点位于2号外显子两侧。若与Cre品系小鼠交配的后代可在Cre酶表达的组织中条件性敲除该基因。雄性基因敲除纯合子小鼠可能出现体重降低、体型偏小、葡萄糖耐受受损、血清葡萄糖上升、血清胰岛素和beta细胞胰岛素释放减少等表型。
应用领域:非酒精性脂肪肝

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