F8-KO(2)

品系全名

C57BL/6JSmo-F8em3Smoc

目录号

NM-KO-200608

品系状态

胚胎冻存

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基因信息

基因名
F8

基因曾用名

Cf8; Cf-8; FVIII

NCBI ID

14069

MGI ID

88383

Ensembl ID

ENSMUSG00000031196

Pubmed

F8

人类同源基因

F8

品系描述

通过敲除F8基因exon 1-26，建立F8-KO(2)小鼠模型。与此相似的品系还有F8-KO(NM-KO-00012),敲除区域为exon 16-19。
应用领域：血友病、F8因子缺失相关凝血机制研究和药物试验

疾病预测

血友病
Hemophilia

近似模型的表型

MGI:2449544

参考文献

Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr, Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A [letter]. Nat Genet. 1995 May;10(1):119-21

验证数据

4.png

图1. 不同品系F8敲除小鼠活化部分凝血活酶时间（APTT）检测。结果显示F8-KO(2)（NM-KO-200608）凝血所需时间明显长于野生型小鼠，且F8-KO（NM-KO-00012）与F8-KO(2)（NM-KO-200608）凝血时间无明显差别，表型类似。


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