Apc-Flox

品系全名

C57BL/6JSmo-Apctm2(flox)Smoc

目录号

NM-CKO-200013

品系状态

活体

导出PDF

基因信息

基因名
Apc

基因曾用名

CC1， Min， mAPC， AI047805， AU020952， AW124434

NCBI ID

11789

MGI ID

88039

Ensembl ID

ENSMUSG00000005871

Pubmed

Apc

人类同源基因

APC

品系描述

在Apc基因exon 15两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Apc基因的小鼠模型。
应用领域：肠道肿瘤相关研究

疾病预测

大肠癌
Colorectal Cancer

近似模型的表型

MGI:3844311
注：该品系与CDX2-cre工具鼠交配才可能获得预期表型

参考文献

Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER, Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res. 2007 Oct 15;67(20):9721-30

大肠癌
Colorectal Cancer

近似模型的表型

MGI:4456428
注：该品系与Fabp1-cre工具鼠交配才可能获得预期表型

参考文献

Robanus-Maandag EC, Koelink PJ, Breukel C, Salvatori DC, Jagmohan-Changur SC, Bosch CA, Verspaget HW, Devilee P, Fodde R, Smits R, A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis. 2010 May;31(5):946-52

大肠癌
Colorectal Cancer

近似模型的表型

MGI:5702414
注：该品系与Vil1-cre/ERT2工具鼠交配才可能获得预期表型

参考文献

Levy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M, Couty JP, Romagnolo B, Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol. 2015 Aug;17(8):1062-73

家族性腺瘤性息肉病
Familial Adenomatous Polyposis

近似模型的表型

MGI:3590232
注：该品系与Lck-cre工具鼠交配才可能获得预期表型

参考文献

Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K, Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5583019
注：该品系与Pgr-Cre工具鼠交配才可能获得预期表型

参考文献

van der Horst PH, van der Zee M, Heijmans-Antonissen C, Jia Y, DeMayo FJ, Lydon JP, van Deurzen CH, Ewing PC, Burger CW, Blok LJ, A mouse model for endometrioid ovarian cancer arising from the distal oviduct. Int J Cancer. 2014 Sep 1;135(5):1028-37

卵巢癌
Ovarian Cancer

近似模型的表型

MGI:5779541
注：该品系与Pten-Flox(NM-CKO-18004)和Ad-Cre工具鼠交配并注射Ad-Cre才可能获得预期表型

参考文献

Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR, Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 2007 Apr;11(4):321-33

胰腺粘液性囊腺瘤
Pancreatic Mucinous Cystadenoma

近似模型的表型

MGI:5898453
注：该品系与P53-Flox(2)(NM-CKO-190067)和Pdx1-cre工具鼠交配才可能获得预期表型

参考文献

Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34

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