Pnliprp1-KO

品系全名

B6;129S-Pnliprp1tm1Smoc

目录号

NM-KO-00005

品系状态

胚胎冻存

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基因信息

基因名
Pnliprp1

品系描述

缺失Pnliprp1基因的小鼠成年后将发生肥胖,并表现出糖尿病早期的某些症状。病理学检测显示,尽管小鼠体内脂肪细胞的数量无显著变化,但脂肪细胞的体积明显增大,使得小鼠体内脂肪含量增加,导致肥胖。同时该小鼠成年后也表现出了肥胖病患者和糖尿病人早期所具有的葡萄糖耐受和胰岛素抵抗现象。将有助于科研人员找到和治疗肥胖及相关疾病的靶点和药物。 Plrp1 KO mice displayed mature-onset obesity with increased fat mass, impaired glucose
应用领域:脂肪代谢、肥胖、糖尿病

发表文献 2篇

1. Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice
发表年份:2022 来源杂志:Journal of Orthopaedic Translation

2. Osteoprotegerin deficiency causes morphological and quantitative damage in epithelial rests of Malassez
发表年份:2018 来源杂志:JOURNAL OF MOLECULAR HISTOLOGY

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