Hif1a-Flox

品系全名

C57BL/6JSmo-Hif1atm1(flox)Smoc

目录号

NM-CKO-190065

品系状态

活体

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基因信息

基因名
Hif1a

基因曾用名

MOP1; bHLHe78; AA959795; HIF1alpha; HIF1-alpha; HIF-1-alpha

NCBI ID

15251

MGI ID

106918

Ensembl ID

ENSMUSG00000021109

Pubmed

Hif1a

人类同源基因

HIF1A

品系描述

在Hif1a基因exon 2两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Hif1a基因的小鼠模型。
应用领域：低氧诱导因子，和代谢疾病以及肿瘤研究相关

疾病预测

von Hippel-Lindau病
Von Hippel-Lindau Disease

近似模型的表型

MGI:3621461
注：该品系与Vhl-Flox(2)(NM-CKO-200232)和Pck1-cre工具鼠交配才可能获得预期表型

参考文献

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

糖原贮积病七
Glycogen Storage Disease Vii

近似模型的表型

MGI:3621470
注：该品系与Ckmm-cre工具鼠交配才可能获得预期表型

参考文献

Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS, Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004 Oct;2(10):e288

发表文献 1篇

1. Loss of sphingosine kinase 2 promotes the expansionof hematopoietic stem cells by improving theirmetabolic fitness
发表年份：2022 来源杂志：blood

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