Pd-1-KO

品系全名

C57BL/6JSmo-Pdcd1em3Smoc

目录号

NM-KO-190423

品系状态

活体

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基因信息

基因名
Pdcd1

基因曾用名

PD-1; Pdc1; Ly101

NCBI ID

18566

MGI ID

104879

Ensembl ID

ENSMUSG00000026285

Pubmed

Pdcd1

人类同源基因

PDCD1

品系描述

敲除Pdcd1基因 exon2-4，获得Pdcd1基因敲除小鼠。
应用领域：免疫相关

疾病预测

膀胱炎
Cystitis

近似模型的表型

MGI:5574062
注：该品系需与Fcgr2b-KO(3)(NM-KO-210279)交配才可能获得预期表型

参考文献

Sugino Y, Nishikawa N, Yoshimura K, Kuno S, Hayashi Y, Yoshimura N, Okazaki T, Kanematsu A, Ogawa O, BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Sci Rep. 2012;2:317

扩张型心肌病
Dilated Cardiomyopathy

近似模型的表型

MGI:3054645

参考文献

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T, Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001 Jan 12;291(5502):319-22

系统性红斑狼疮
Systemic Lupus Erythematosus

近似模型的表型

MGI:3054643

参考文献

Nishimura H, Minato N, Nakano T, Honjo T, Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72

验证数据

image.png

Fig.1 Detection of PD-1 expression in Spleen in Pd-1 KO mice.

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Fig.2 Detection of PD-1 expression in Peripheral blood in Pd-1-KO mice.

发表文献 2篇

1. UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
发表年份：2024 来源杂志：MOLECULAR CELL

2. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity
发表年份：2021 来源杂志：Mucosal Immunology

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