Zap70-W163C(Balb/c)
品系全名
BALB/cJSmo-Zap70em(W163C)Smoc
目录号
NM-KI-210366
品系状态
活体
基因信息
基因名
Zap70
品系描述
疾病预测
Rheumatoid Arthritis
验证数据
Fig.1 Clinical score of joint swelling in HO Zap70-W163C (Balb/C) mice(A) and representative diagram of hind limb joints of mice in each group on day 52(B) (female, 6-8wks). Compared with the control group, the mannan-induced mice gradually increased their joint swelling scores over time.
Signs of arthritis were assessed by a visual score where 0= Normal paw, 1 = one toe inflamed or swollen, 2 = more than one toe, but not entire paw, or mild swelling of the entire paw, 3 = entire paw inflamed and swollen, and 4 = very inflamed and swollen paw or ankylosed paw.
Fig.2 Hindlimb micro-CT image of HO Zap70-W163C(Balb/C) mice in the control (G1) and model groups (G2) (female, 6-8wks). The orange arrows point to osteophytes.
Fig.3 Score of HO Zap70-W163C(Balb/C) mice (A) and H&E pathology(B). (female, 6-8wks, n=3)
Compared with G1, the infiltration of mixed inflammatory cells in the induced group was significantly increased, and the synovial membrane of the joints showed obvious hyperplasia, pannu formation, fibrous tissue formation, and cartilage erosion.
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