Mus81-KO

品系全名

C57BL/6JSmo-Mus81em1Smoc

目录号

NM-KO-200638

品系状态

胚胎冻存

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基因信息

基因名
Mus81

基因曾用名

AI182501; AW045863; 1200008A18Rik

NCBI ID

71711

MGI ID

1918961

Ensembl ID

ENSMUSG00000024906

Pubmed

Mus81

人类同源基因

MUS81

品系描述

敲除Mus81基因exon 1-5，建立Mus81基因敲除小鼠模型。
应用领域：同源DNA配对和链交换以及DNA双链断裂修复相关研究

疾病预测

肺气肿
Pulmonary Emphysema

近似模型的表型

MGI:5661527

参考文献

Ramnath NW, van de Luijtgaarden KM, van der Pluijm I, van Nimwegen M, van Heijningen PM, Swagemakers SM, van Thiel BS, Ridwan RY, van Vliet N, Vermeij M, Hawinkels LJ, de Munck A, Dzyubachyk O, Meijering E, van der Spek P, Rottier R, Yanagisawa H, Hendriks RW, Kanaar R, Rouwet EV, Kleinjan A, Essers J, Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema. PLoS One. 2014;9(9):e106054

马凡综合征
Marfan Syndrome

近似模型的表型

MGI:3794044

参考文献

Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MG, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J, Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res. 2007 Mar 16;100(5):738-46

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