Slc6a1-KO

品系全名

B6;129S-Slc6a1tm1Smoc

目录号

NM-KO-00002

品系状态

活体

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基因信息

基因名
Slc6a1

基因曾用名

Gabt; Gat1; XT-1; GAT-1; Gabt1; Xtrp1; GABATR; GABATHG; A730043E01

NCBI ID

232333

MGI ID

95627

Ensembl ID

ENSMUSG00000030310

Pubmed

Slc6a1

人类同源基因

SLC6A1

品系描述

基因剔除纯合子小鼠表现为突触后抑制性电位异常、GABA重摄取和释放异常、超动和多种行为学异常表型。敲除区域为exon 2-3。与此相似的品系还有Slc6a1-KO(2)，敲除区域为exon 6。
应用领域：神经系统、免疫系统等相关研究

疾病预测

精神分裂症
schizophrenia

近似模型的表型

MGI:5559028

参考文献

Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84:255-67

精神分裂症
schizophrenia

近似模型的表型

MGI:5559028

参考文献

Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84:255-67

精神分裂症
Schizophrenia

近似模型的表型

MGI:5559028

参考文献

Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84:255-67

精神分裂症
schizophrenia

近似模型的表型

MGI:5559028

参考文献

Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84:255-67

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