Gipr-KO

品系全名

C57BL/6Smoc-Giprem1Smoc

目录号

NM-KO-200225

品系状态

活体

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基因信息

基因名
Gipr

品系描述

敲除Gipr基因exon 3,建立Gipr基因敲除小鼠模型。
应用领域:治疗性抗体靶点

验证数据

image.png

Fig.1 Detection of Gipr expression in the frontal lobe and testis by RT-PCR. 

Wild type: one band at 155 bp with primers F1/R1(mGipr) and one band at 123 bp with primers F/R(mGapdh). 

Homozygous: only one band at 123 bp with primers F/R(mGapdh). 

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Oral glucose tolerance test (OGTT) results.  (n=4/group, male)

Mice were randomly grouped and fasted for 4~6 h. All groups were administered glucose (1 g/kg) by oral gavage, and blood glucose levels were monitored at the indicated time points. Data in figure B were normalized to the baseline (0 min) value of each individual mouse. 

Results are expressed as mean ± SEM. Statistical analysis was performed using an unpaired two-tailed Student’s t-test; * P < 0.05, ** P < 0.01.


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