C3-KO

品系全名

C57BL/6JSmo-C3em1Smoc

目录号

NM-KO-191193

品系状态

活体

导出PDF

基因信息

基因名
C3

品系描述

敲除C3基因exon 2,建立C3基因敲除小鼠模型。曾有基因修饰致死报导,详情点击基因信息中的MGI ID。
应用领域:免疫相关

疾病预测

补体成分 3 缺乏
Complement Component 3 Deficiency

验证数据

image.png

Fig. 1 Detection of C3 expression in thymus by RT-PCR (male mice for both groups). 

Wild type: one band at 225 bp with primers F1/R1(mC3) and one band at 123 bp with primers F/R(mGapdh). 

Homozygous: no band with primers F1/R1(mC3) and one band at 123 bp with primers F/R(mGapdh). 

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig. 2 Detection of mouse C3 expression in serum by ELISA. (1 male WT C57BL/6 mouse and 3 male HO C3-KO mice)

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.



发表文献 1篇


你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看