Nlrp3-KO

品系全名

C57BL/6JSmo-Nlrp3em3Smoc

目录号

NM-KO-190428

品系状态

活体

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基因信息

基因名
Nlrp3

基因曾用名

FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL

NCBI ID

216799

MGI ID

2653833

Ensembl ID

ENSMUSG00000032691

Pubmed

Nlrp3

人类同源基因

NLRP3

品系描述

敲除Nlrp3基因的exon 5 区域，获得Nlrp3基因敲除小鼠模型。曾有基因修饰致死报导，详情点击基因信息中的MGI ID。
应用领域：免疫相关

发表文献 16篇

1. Inhibiting the P2X7R-NLRP3 inflammasome pathway regulates CXCL16 to alleviate podocyte injury in mice with adriamycin nephropathy
发表年份：2026 来源杂志：Scientific Reports

2. Salmonella Enteritidis SpaO protein regulating inflammasome activation in macrophage
发表年份：2026 来源杂志：MICROBIAL PATHOGENESIS

3. Secondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation
发表年份：2025 来源杂志：Advanced Science

4. Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy
发表年份：2025 来源杂志：International Journal of Biological Sciences

5. JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models
发表年份：2025 来源杂志：Cell Communication and Signaling

6. Potentilla freyniana Bornm. and its active component Tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κB/NLRP3 signaling pathway
发表年份：2025 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

7. Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages
发表年份：2024 来源杂志：INTERNATIONAL IMMUNOPHARMACOLOGY

8. Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury
发表年份：2024 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

9. Salmonella Enteritidis antitoxin DinJ inhibits NLRP3-dependent canonical inflammasome activation in macrophages
发表年份：2024 来源杂志：INFECTION AND IMMUNITY

10. Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway
发表年份：2023 来源杂志：PLoS Pathogens

11. Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition
发表年份：2023 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

12. Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin
发表年份：2022 来源杂志：BRITISH JOURNAL OF PHARMACOLOGY

13. NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma
发表年份：2022 来源杂志：CANCER IMMUNOLOGY IMMUNOTHERAPY

14. IL-9 blockade attenuates inflammation in a murine model of mechanical ventilation-induced lung injury by inhibiting the NLRP3 inflammasome pathway
发表年份：2022 来源杂志：INFLAMMOPHARMACOLOGY

15. Salmonella Enteritidis GalE Protein Inhibits LPS-Induced NLRP3 Inflammasome Activation
发表年份：2022 来源杂志：Microorganisms

16. Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation
发表年份：2021 来源杂志：Translational Psychiatry

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