Nr1h4-KO

品系全名

C57BL/6JSmo-Nr1h4em1Smoc

目录号

NM-KO-190328

品系状态

活体

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基因信息

基因名
Nr1h4

基因曾用名

Fxr; HRR1; RIP14; Rxrip14; AI957360

NCBI ID

20186

MGI ID

1352464

Ensembl ID

ENSMUSG00000047638

Pubmed

Nr1h4

人类同源基因

NR1H4

品系描述

敲除Nr1h4基因的exon 9 区域，获得Nr1h4基因敲除小鼠模型。
应用领域：免疫相关

疾病预测

肝细胞癌
Hepatocellular Carcinoma

近似模型的表型

MGI:2175162

参考文献

Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ, Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis. 2007 May;28(5):940-6

发表文献 12篇

1. Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis
发表年份：2026 来源杂志：CELL DEATH AND DIFFERENTIATION

2. Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling
发表年份：2025 来源杂志：Journal of Advanced Research

3. Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice
发表年份：2025 来源杂志：BMC Medicine

4. Farnesoid X receptor regulates CYP1A1 and CYP1B1 and estradiol metabolism in mouse and human cell lines
发表年份：2025 来源杂志：CHEMICO-BIOLOGICAL INTERACTIONS

5. Yinchen-Gancao decoction ameliorated NASH in mice by reducing hepatic lipid accumulation, inhibiting hepatic inflammatory and endoplasmic reticulum stress
发表年份：2025 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

6. Geniposide dosage and administration time: balancing therapeutic benefits and adverse reactions in liver disease treatment
发表年份：2024 来源杂志：PHYTOMEDICINE

7. Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway
发表年份：2023 来源杂志：CLINICAL SCIENCE

8. Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo
发表年份：2023 来源杂志：Frontiers in Pharmacology

9. Yinchen decoction protects against cholic acid diet-induced cholestatic liver injury in mice through liver and ileal FXR signaling
发表年份：2023 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

10. Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis
发表年份：2023 来源杂志：JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

11. The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway
发表年份：2023 来源杂志：JOURNAL OF APPLIED TOXICOLOGY

12. Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma
发表年份：2021 来源杂志：Frontiers in Oncology

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