Cth-KO

品系全名

C57BL/6JSmo-Cthem1Smoc

目录号

NM-KO-2114077

品系状态

精子冻存

导出PDF

基因信息

基因名
Cth

品系描述

通过敲除Cth基因exon 2,建立Cth基因敲除小鼠模型。

疾病预测

胱硫醚尿症
Cystathioninuria

鉴定报告

下载

发表文献 19篇

1. Cystathionine γ-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle
发表年份:2025 来源杂志:REDOX REPORT

2. Hydrogen sulfide inhibits lipopolysaccharide-based neuroinflammation-induced astrocyte polarization after cerebral ischemia/reperfusion injury
发表年份:2023 来源杂志:EUROPEAN JOURNAL OF PHARMACOLOGY

3. Cystathionine γ-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure
发表年份:2023 来源杂志:REDOX REPORT

4. Reduced hydrogen sulfide production contributes to adrenal insufficiency induced by hypoxia via modulation of NLRP3 inflammasome activation
发表年份:2023 来源杂志:REDOX REPORT

5. Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction
发表年份:2022 来源杂志:Redox Biology

6. Methionine Restriction Prevents Lipopolysaccharide-Induced Acute Lung Injury via Modulating CSE/H2S Pathway
发表年份:2022 来源杂志:Nutrients

7. Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca2+-activated K+ channels
发表年份:2021 来源杂志:BRITISH JOURNAL OF PHARMACOLOGY

8. Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes
发表年份:2021 来源杂志:Oxidative Medicine and Cellular Longevity

9. CSE-Derived H2S Inhibits Reactive Astrocytes Proliferation and Promotes Neural Functional Recovery after Cerebral Ischemia/Reperfusion Injury in Mice Via Inhibition of RhoA/ROCK2 Pathway
发表年份:2021 来源杂志:ACS Chemical Neuroscience

10. Cystathionine gamma-lyase aggravates periodontal damage in traumatic occlusion mouse models
发表年份:2020 来源杂志:JOURNAL OF PERIODONTAL RESEARCH

11. Cystathionine γ-lyase-H2S facilitates mandibular defect healing via inducing osteogenic differentiation of bone marrow mesenchymal stem cells
发表年份:2020 来源杂志:ARCHIVES OF ORAL BIOLOGY

12. Cystathionine gamma lyase aggravates orthodontic root resorption in mice
发表年份:2019 来源杂志:Annals of Translational Medicine

13. Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice
发表年份:2018 来源杂志:CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

14. Cystathionine gamma lyase-H2S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading
发表年份:2018 来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

15. Endogenous hydrogen sulfide regulates histone demethylase JMJD3-mediated inflammatory response in LPS-stimulated macrophages and in a mouse model of LPS-induced septic shock
发表年份:2017 来源杂志:BIOCHEMICAL PHARMACOLOGY

16. New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS
发表年份:2017 来源杂志:Scientific Reports

17. Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages
发表年份:2016 来源杂志:ANTIOXIDANTS & REDOX SIGNALING

18. Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation
发表年份:2016 来源杂志:ANTIOXIDANTS & REDOX SIGNALING

19. miRNA-30 Family Inhibition Protects Against Cardiac Ischemic Injury by Regulating Cystathionine-γ-Lyase Expression
发表年份:2015 来源杂志:ANTIOXIDANTS & REDOX SIGNALING

展开

你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。

查看

【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式,包括基因定点修饰的小鼠命名,比如:敲除、敲入、点突变等等,和随机转基因的小鼠命名。

查看

Cre-lox系统介绍及使用汇总

你一定听说过Cre-lox重组系统,无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点,如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统,可以在特定细胞、组织或整个生物体,甚至在特定时间点敲除或表达某个基因,实现对特定基因的时空特异性操作,这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。

查看