Tlr4-KO

品系全名

C57BL/6JSmo-Tlr4em1Smoc

目录号

NM-KO-18052

品系状态

活体

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基因信息

基因名
Tlr4

品系描述

敲除Tlr4基因的exon 2区域,获得Tlr4基因敲除小鼠模型。
应用领域:免疫相关

疾病预测

肺气肿
Pulmonary Emphysema

发表文献 10篇

1. Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells
发表年份:2025 来源杂志:Nature Communications

2. Bacteroides dorei RX2020-derived bile acid alleviates influenza virus infection through TGR5 signaling
发表年份:2025 来源杂志:Cell Communication and Signaling

3. Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation
发表年份:2025 来源杂志:MOLECULAR MEDICINE

4. Pseudomonas aeruginosa-derived extracellular vesicles enhance macrophage aerobic glycolysis that fuels inflammation
发表年份:2025 来源杂志:Frontiers in Microbiology

5. S100a8/a9 regulated by LPS/TLR4 axis plays an important role in Salmonella-based tumor therapy and host defense
发表年份:2024 来源杂志:INTERNATIONAL JOURNAL OF CANCER

6. Maternal antibiotic treatment during pregnancy attenuates the transport and absorption of maternal antibody IgG through TLR4 and TLR2 receptor
发表年份:2023 来源杂志:Frontiers in Microbiology

7. Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
发表年份:2022 来源杂志:Cell Host & Microbe

8. CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage
发表年份:2022 来源杂志:Frontiers in Immunology

9. The involvement of DAMPs-mediated inflammation in cyclophosphamide-induced liver injury and the protection of liquiritigenin and liquiritin
发表年份:2019 来源杂志:EUROPEAN JOURNAL OF PHARMACOLOGY

10. Mnn10 Maintains Pathogenicity in Candida albicans by Extending α-1,6-Mannose Backbone to Evade Host Dectin-1 Mediated Antifungal Immunity
发表年份:2016 来源杂志:PLoS Pathogens

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