Slco1b2\Slco1a5-KO
品系全名
C57BL/6Smoc-Slco1b2em1Slco1a5em1Smoc
目录号
NM-KO-18030
品系状态
精子冻存
品系描述
敲除Slco1b2基因exon4-16,同时敲除Slco1a5基因的exon 3-15，建立Slco1b2和Slco1a5基因敲除小鼠模型。OATP促进多种有机内源和外源化合物的钠非依赖性摄取转运，例如胆汁酸，类固醇和甲状腺激素及其缀合物，以及许多药物和毒素，该敲除小鼠有助于研究Slco1a/1b家族在这些过程中的贡献。
*使用本品系发表的文献需注明: Slco1b2\Slco1a5-KO mice (Cat. NO. NM-KO-18030) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 Detection of Slco1a1, Slco1a4, Slco1a5 and Slco1b2 expression in the liver by RT-PCR.
Wild type: one band at 140 bp with primers F1/R1(mSlco1a1), one band at 350 bp with primers F2/R2(mSlco1a4), one band at 110 bp with primers F3/R3(mSlco1a5), one band at 170 bp with primers F4/R4(mSlco1b2) and one band at 123 bp with primers F/R(mGapdh).
Homozygous: only one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
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