Tmem173-KO

品系全名

C57BL/6JSmo-Tmem173em1Smoc

目录号

NM-KO-2105967

品系状态

活体

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品系描述

敲除Tmem173基因exon 4-6，建立Tmem173基因敲除小鼠模型。

验证数据

image.png

Fig.1 Detection of mouse Tmem173 expression in the female C57BL/6 WT mouse (8-10 weeks old) and Tmem173-KO mice (9 weeks old) by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

发表文献 12篇

1. STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis
发表年份：2026 来源杂志：IMMUNOLOGY

2. Disturbance of cytoskeleton induced by ligustilide promotes hepatic stellate cell senescence and ameliorates liver fibrosis
发表年份：2025 来源杂志：Theranostics

3. Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
发表年份：2025 来源杂志：Cell Reports Medicine

4. cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia
发表年份：2025 来源杂志：Journal of Neuroinflammation

5. STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection
发表年份：2025 来源杂志：Journal of Neuroinflammation

6. ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury
发表年份：2025 来源杂志：Clinical and Translational Medicine

7. miR-208a-3p Targets PPP6C to Regulate the Progression of Radiation-Induced Pneumonia
发表年份：2025 来源杂志：ANTIOXIDANTS & REDOX SIGNALING

8. Glycolysis drives STING signaling to facilitate dendritic cell antitumor function
发表年份：2023 来源杂志：JOURNAL OF CLINICAL INVESTIGATION

9. Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury
发表年份：2023 来源杂志：Cell Death Discovery

10. XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression
发表年份：2022 来源杂志：JHEP Reports

11. Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling
发表年份：2022 来源杂志：CELL PROLIFERATION

12. Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation
发表年份：2022 来源杂志：BIOCHEMICAL PHARMACOLOGY

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