C57BL/6

品系全名

C57BL/6

目录号

SM-001

品系状态

活体

导出PDF

品系描述

是第一个完成基因组测序的小鼠品系,毛色为黑色,被认作"标准"的近交系,为许多突变基因提供遗传背景。具有品系稳定、易于繁殖,应激反应均一,试验结果精度高等特点。

验证数据

image.png

图1.C57BL/6小鼠生长曲线(n=840)。

image.png

图2.C57BL/6小鼠血常规检测。



发表文献

Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
来源杂志:Signal Transduction and Targeted Therapy

Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
来源杂志:Advanced Science

High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
来源杂志:Advanced Science

Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
来源杂志:Cell Death & Disease

Extracellular vesicles for delivery of functional telomerase
来源杂志:Cell Communication and Signaling

An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity
来源杂志:MATERIALS & DESIGN

Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
来源杂志:Cell Reports

Therapeutic Efficacy and Mechanistic Insights of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Chemotherapy-Induced Oral Mucositis
来源杂志:JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life
来源杂志:Scientific Reports

Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma
来源杂志:CELLULAR SIGNALLING

A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury
来源杂志:RENAL FAILURE

USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
来源杂志:American Journal of Cancer Research

Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression
来源杂志:DIGESTIVE DISEASES AND SCIENCES

Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from mice
来源杂志:STAR Protocols


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