C57BL/6

品系全名

C57BL/6Smoc

目录号

SM-001

品系状态

活体

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品系描述

是第一个完成基因组测序的小鼠品系，毛色为黑色，被认作"标准"的近交系，为许多突变基因提供遗传背景。具有品系稳定、易于繁殖，应激反应均一，试验结果精度高等特点。

验证数据

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图1.C57BL/6小鼠生长曲线（n=840）。

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图2.C57BL/6小鼠血常规检测。


发表文献 16篇

1. Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
发表年份：2025 来源杂志：Signal Transduction and Targeted Therapy

2. Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
发表年份：2025 来源杂志：Advanced Science

3. High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
发表年份：2025 来源杂志：Advanced Science

4. Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
发表年份：2025 来源杂志：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

5. Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
发表年份：2025 来源杂志：Cell Death & Disease

6. Extracellular vesicles for delivery of functional telomerase
发表年份：2025 来源杂志：Cell Communication and Signaling

7. An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity
发表年份：2025 来源杂志：MATERIALS & DESIGN

8. Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
发表年份：2025 来源杂志：Cell Reports

9. Therapeutic Efficacy and Mechanistic Insights of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Chemotherapy-Induced Oral Mucositis
发表年份：2025 来源杂志：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

10. Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life
发表年份：2025 来源杂志：Scientific Reports

11. Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma
发表年份：2025 来源杂志：CELLULAR SIGNALLING

12. A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury
发表年份：2025 来源杂志：RENAL FAILURE

13. USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
发表年份：2025 来源杂志：American Journal of Cancer Research

14. Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression
发表年份：2025 来源杂志：DIGESTIVE DISEASES AND SCIENCES

15. Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from mice
发表年份：2025 来源杂志：STAR Protocols

16. Extending dual-targeting upper-limit in liposomal delivery of lithospermic acid B for Alzheimer's mitochondrial revitalization
发表年份：2024 来源杂志：JOURNAL OF CONTROLLED RELEASE

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