hCRLF2

品系全名

C57BL/6Smoc-Crlf2em1(hCRLF2)Smoc

目录号

NM-HU-210028

品系状态

活体

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基因信息

基因名
Crlf2

基因曾用名

CRLM2; Ly114; Tpte2; Tslpr

NCBI ID

57914

MGI ID

1889506

Ensembl ID

ENSMUSG00000033467

Pubmed

Crlf2

人类同源基因

CRLF2

品系描述

利用ES细胞打靶方式，将小鼠Crlf2基因全部或者部分替换为人源CRLF2。从而表达人或人鼠嵌合CRLF2蛋白，取代小鼠内源Crlf2蛋白的表达。
应用领域：免疫治疗；药物筛选

验证数据

image.png

Fig.1 Detection of hCRLF2 expression in the bone marrow of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.2 Detection of hCRLF2 expression in the blood of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hCRLF2 expression in the spleen of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of mCRLF2 expression in the bone marrow of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of mCRLF2 expression in the blood of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of mCRLF2 expression in the spleen of hCRLF2 knockin mice. (male, 13-week-old)

Abbr.  WT, wild type; HO, homozygous.

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