B2m-KO(M-NSG)

品系全名

M-NSG-B2memSmoc

目录号

NM-NSG-002

品系状态

胚胎冻存

导出PDF

基因信息

基因名
B2M

品系描述

敲除B2m基因exon 2-3区域,获得M-NSG背景B2m基因敲除小鼠模型,是异种移植物移植研究的理想模型,也可用于为移植研究提供无胰岛炎、无MHC I类胰岛组织。
应用领域:免疫缺陷,免疫系统,移植研究

验证数据


image.png

Fig 1. Expression characterization of mouse MHC I and MHC II in bone marrow, blood, spleen in B2m-KO(NMG) mice.

image.png


Fig 2. Body weight growth curve of huPBMC-B2m-KO(NMG) mice.

image.png

Fig 3. Survival rate of huPBMC-B2m-KO(NMG) mice.

image.png

Fig 4. GvHD scores of huPBMC-B2m-KO(NMG) mice.

image.png

Fig 5. Percentage of hCD45-positive cells of huPBMC-B2m-KO(NMG) mice.

image.png

Fig 6. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-B2m-KO(NMG) mice.


你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看