hIL2/hIL2RA

品系全名

C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

目录号

NM-HU-200275

品系状态

胚胎冻存

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基因信息

基因名

品系描述

通过hIL2(NM-HU-190048)与hIL2R(NM-HU-190064)小鼠交配获得
应用领域:肿瘤研究;免疫治疗;药物筛选

验证数据

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Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

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Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).

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Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).

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Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).

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Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).


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