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小鼠

Brip1-KO

品系名：C57BL/6Smoc-Brip1em1Smoc
品系状态：在研 | 目录号：待定

敲除Brip1基因exon 3，建立Brip1基因敲除小鼠模型。

小鼠

Brip1-Flox

品系名：C57BL/6Smoc-Brip1em1(flox)Smoc
品系状态：在研 | 目录号：待定

在Brip1基因目的exons两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Brip1基因的小鼠模型。

小鼠

Cd24a-KO

品系名：C57BL/6JSmo-Cd24aem1Smoc
品系状态：精子冻存 | 目录号：NM-KO-190031

敲除Cd24a基因的exon 1-2 区域，获得Cd24a基因敲除小鼠模型。

小鼠

Dhtkd1-Y485X

品系名：B6;129S-Dhtkd1tm1Smoc
品系状态：胚胎冻存 | 目录号：NM-KI-00005

These mice carry a Y485X mutation of Dhtkd1 gene.

小鼠

Upk3b-KO

品系名：B6;129S-Upk3btm1Smoc
品系状态：胚胎冻存 | 目录号：NM-KO-00023

An Frt-Neo-Frt cassette replaced exons 1-2 of Upk13 gene.

小鼠

Oosp1-KO

品系名：B6;129S-Oosp1tm1Smoc
品系状态：胚胎冻存 | 目录号：NM-KO-00030

An Frt-Neo-Frt cassette replaced exons 2-3 of Oosp1 gene.

小鼠

Anp32b-Flox

品系名：B6;129S-Anp32btm1(flox)Smoc
品系状态：胚胎冻存 | 目录号：NM-CKO-00043

These Anp32b flox mice possess loxP sites flanking exon 4 of the targeted Anp32b gene. Mice homozygous for a knock-out allele exhibit partial perinatal lethality associated with failure to initiate breathing, craniofacial defects, enlarged brain ventricl

小鼠

Rps4l-Flox(AI)

品系名：C57BL/6JSmo-Rps4lem2(flox)Smoc
品系状态：精子冻存 | 目录号：NM-CKO-242022

通过在Rps4l基因exon 1敲入人工内含子。该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Rps4l基因的小鼠模型。构建策略参考文献CRISPR-Cas9-mediated insertion of a short artificial intron for the generation of conditional alleles in mice。

小鼠

Crhr1/N-EGFP-Flox

品系名：C57BL/6JSmo-Crhr1em1(N-EGFP, flox)Smoc
品系状态：精子冻存 | 目录号：NM-CKO-2100082

在Crhr1基因目的exon 2两侧分别插入loxP位点。EGFP元件位于Crhr1基因exon 2。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Crhr1基因的小鼠模型。构建策略参考文献Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

小鼠

CAG-LSL-dCas9-SPH-Tg

品系名：C57BL/6JSmo-Tg(CAG-LSL-dCas9-SPH)Smoc
品系状态：活体 | 目录号：NM-TG-00025
发表文献：1篇

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *该品系为客户捐赠品系，捐赠者发表文献荧光观察采用免疫荧光的方法，JAX关于该品系描述也明确无法直接观察到荧光。

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