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Models

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hCTLA-4/4-1BB

品系名:C57BL/6Smoc-Ctla4tm1(hCTLA4) Tnfrsf9tm1(hTNFRSF9) /Smoc
品系状态:胚胎冻存 | 目录号:NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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Ifngr1/Ifnar1-KO

品系名:C57BL/6Smoc-Ifngr1em1Ifnar1em1Smoc
品系状态:活体 | 目录号:NM-KO-190425
验证数据:有

This Ifngr1 and Ifnar1 double knockout strain is established by crossing Ifngr1-KO and Ifnar1-KO mice together.

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hSIRPA(2)/hCD47

品系名:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
品系状态:活体 | 目录号:NM-HU-2000111
验证数据:有

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

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hLAG3/hCTLA-4

品系名:B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
品系状态:活体 | 目录号:NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

小鼠

Slc6A12-KO

品系名:B6;129S-Slc6a12tm1Smoc
品系状态:胚胎冻存 | 目录号:NM-KO-00047

Exon 1 and exon 2 were replaced by Neo cassette.

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Btbd10-KO

品系名:B6;129S-Btbd10tm1Smoc
品系状态:胚胎冻存 | 目录号:NM-KO-00043

Exon 6 and exon 7 were replaced by Neo cassette.

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Gpr142-KO

品系名:B6;129S-Gpr142tm1Smoc
品系状态:胚胎冻存 | 目录号:NM-KO-00058

Exon 1 and exon 2 were replaced by Neo cassette.

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Gpr61-KO

品系名:B6;129S-Gpr61tm1Smoc
品系状态:胚胎冻存 | 目录号:NM-KO-00060

Exon 2 and exon 3 were replaced by Neo cassette.

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Mir29b2/Mir29c-KO

品系名:C57BL/6Smoc-Mir29b-2em1 Mir29cem1Smoc
品系状态:胚胎冻存 | 目录号:NM-KO-00080

Mir29b-2 and Mir29c are located in 3'UTR region of Cd46 gene. a 0.7kb region in length including Mir29b-2 and Mir29c pre-microRNAs was removed in this strain.

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Eif4ebp1-KO

品系名:C57BL/6Smoc-Eif4Ebp1em1Smoc
品系状态:精子冻存 | 目录号:NM-KO-191088

Exon 1 and exon 2 of Eif4ebp1 gene was deleted to generate Eif4ebp1 knockout mice.

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