Super-trillion Innovative Antibody Drug Discovery Platform

The STAL (Super-Trillion Antibody Libraries) discovery platform integrates technologies of phage display and mammalian cell expression, supplemented with fully automated screening and antibody development. The STAL is effective for challenging innovative targets and development of highly difficult drug modalities. It can meet the R&D needs related to the discovery of various innovative biological drugs, including fully human antibodies, humanized single domain antibodies, humanized monoclonal antibodies, bispecific antibodies, multi-specific antibodies, polypeptides, ADC, PDC and miniaturized proteins. The obtained candidates have natural conformations, high affinity and high developability.

The STAL Discovery Platform comprises nine super-trillion antibody libraries, with the number of lead antibodies up to hundreds of times that of canonical antibody discovery technologies. The platform integrates the generation technologies of a variety of biological drugs such as fully human antibodies, humanized antibodies, miniaturized nanobodies, affinitive polypeptides, and affinitive miniaturized proteins, so that it is suitable not only for developing antibodies targeting conventional epitopes, but also for developing antibodies targeting specific epitopes and refined epitopes. Also, the platform seamlessly integrates phage display technology and mammalian cell expression technology so that it is suitable not only for cross-screening with proteins of different species such as human, mouse, and monkey, but also for positive/negative screening of differentiated proteins such as mutation sites, competing antibodies, Fc fusion proteins and His fusion proteins, as well as for complex screening of difficult targets such as cellular antigens, polypeptide antigens, and transmembrane antigens.

The STAL Discovery Platform has been modularly integrated with the Pre-Clinical Integrated Innovative Antibody Drug R&D Platform. As a result, various antibody discovery services, featured technical services and staged technical services can be implemented flexibly, and pre-clinical candidate discovery and integrated R&D of pre-clinical biological drugs can be completed as an one-stop solution. On the basis of this platform, we are also developing an intelligent innovative antibody drug discovery platform.