Analysis of Antibody Specificity
For monoclonal antibody drugs, the multi-specificity of antibody target also brings great risks to the safety of usage, which is a big challenge for their development. Therefore, we launch the service for non-specific binding assessment.
Our specific detection library has included over 2000 target antigen proteins, over 1600 overexpression cell lines, and over 1000 target reference antibodies, which can be used for the rapid evaluation of binding specificity. In the future, the library will also contain over 4500 membrane protein overexpression cell lines to achieve full-target evaluation and facilitate the selection of optimal antibody molecules. In addition, we also provide TCR tests on humans, rhesus monkeys, and rats to assist clients in clinical application.
Service Highlights
1. Over 6500 target recombinant proteins
Extensive target protein library and 7-day protein preparation process enable rapid and comprehensive completion of antibody non-specific evaluation.
2. Over 4500 Membrane protein overexpression cell lines
Multiple target cell libraries and non-specific antibody evaluation based on flow analysis enables accurate determination of non-specific targets.
3. TCR tests on humans, Rhesus monkeys, and rats
33 human tissues, 30 Rhesus monkey tissues, and 30 rat tissues.
4. Rich project testing experience
Accumulated detection experience of dozens of projects, covering proteins, cells, and tissues.
热门文章
Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
查看你一定听说过Cre-lox重组系统,无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点,如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统,可以在特定细胞、组织或整个生物体,甚至在特定时间点敲除或表达某个基因,实现对特定基因的时空特异性操作,这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
查看
