DEN诱导原发性肝癌模型
原理
二乙基亚硝胺（Diethylnitrosamine,DEN）是肝癌的致癌剂，幼鼠腹腔注射后约6个月可建立原发性肝癌模型。
样本要求
雄性C57小鼠周龄16天
服务周期
6个月
技术指标
1）血清检测：生化(ALT、AST、HA、ALB) ；
2）病理检测：HE、MASSON染色；
3）mRNA水平检测：Real-time PCR;
4）蛋白水平检测：Western blot 、FACS；
5）死亡率：幼鼠腹腔注射DEN后，有较高的死亡率。
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