历年文献基因敲除小鼠_转基因小鼠定制

                            
                            Microglial TIA1-mediated stress granules promote neuroinflammation and aggravate neuron loss in mice after ischemic stroke by inhibiting IGF2 signaling
                        

产品名称：Tia1-Flox

研究领域：小胶质细胞; 缺血性卒中

发表年份：2026 发表杂志：Theranostics

                            
                            Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer
                        

产品名称：KPC

研究领域：胰管腺癌; 神经周围浸润; 乳酰化

发表年份：2026 发表杂志：Theranostics

                            
                            Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization
                        

产品名称：Ksr2-KO

研究领域：动脉粥样硬化

发表年份：2026 发表杂志：Theranostics

                            
                            The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation
                        

产品名称：Talin1-Flox; Trp53-Flox

研究领域：骨质疏松症; 骨细胞衰老

发表年份：2026 发表杂志：Theranostics

                            
                            Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury
                        

产品名称：Cdc42-Flox; Cdh16-Cre

研究领域：急性肾损伤

发表年份：2026 发表杂志：International Journal of Biological Sciences

                            
                            NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway
                        

产品名称：Nlrp3-ko

研究领域：帕金森病

发表年份：2026 发表杂志：ACTA PHARMACOLOGICA SINICA

                            
                            α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice
                        

产品名称：C57BL/6

研究领域：氧化应激;疲劳;糖原合成

发表年份：2025 发表杂志：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

                            
                            Native postsynaptic density is a functional condensate formed via phase separation
                        

产品名称：PSD-95-GFP11

研究领域：神经元突触;神经

发表年份：2025 发表杂志：Cell Reports

                            
                            Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury
                        

产品名称：Foxp3-DTR

研究领域：调节性T细胞（Tregs）;脊髓损伤;神经免疫修复

发表年份：2025 发表杂志：Neurotherapeutics

                            
                            STING agonist diABZI confers protection against swine acute diarrhea syndrome coronavirus in neonatal mice by activating antiviral immunity
                        

产品名称：C57BL/6;Sting-KO

研究领域：STING通路;先天免疫反应;人畜共患病

发表年份：2025 发表杂志：JOURNAL OF VIROLOGY

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Microglial TIA1-mediated stress granules promote neuroinflammation and aggravate neuron loss in mice after ischemic stroke by inhibiting IGF2 signaling

Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer

Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization

The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation

Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway

α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice

Native postsynaptic density is a functional condensate formed via phase separation

Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury

STING agonist diABZI confers protection against swine acute diarrhea syndrome coronavirus in neonatal mice by activating antiviral immunity

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