历年文献基因敲除小鼠_转基因小鼠定制

                            
                            CircCDK6 Regulates Stemness Maintenance and Cisplatin Resistance in Lung Adenocarcinoma via the Wnt/β-Catenin Signaling Pathway
                        

产品名称：BALB/c nude

研究领域：肺腺癌;肿瘤干性维持;顺铂耐药;化疗抵抗

发表年份：2026 发表杂志：Cancer Management and Research

                            
                            Liver-originated selective autophagy of BTD by alectinib underlies concurrent hepatotoxicity and dermatotoxicity
                        

产品名称：Alb-Cre

研究领域：选择性自噬;生物素酶;药物不良反应机制

发表年份：2026 发表杂志：Autophagy

                            
                            ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression
                        

产品名称：Zdhhc5-KO

研究领域：胆管癌;棕榈酰化;MAPK通路激活;翻译后脂修饰;肿瘤信号转导

发表年份：2026 发表杂志：CANCER LETTERS

                            
                            Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis
                        

产品名称：C57BL/6

研究领域：姜黄素;肝纤维化;肝星状细胞活化;天然产物靶点

发表年份：2026 发表杂志：LIVER INTERNATIONAL

                            
                            Genetic tools for targeting neuroendocrine cells: Unveiling their plasticity in lung regeneration
                        

产品名称：CGRP-mGFP;Ascl1-CreER

研究领域：神经内分泌细胞;肺再生;细胞可塑性;谱系示踪;再生医学

发表年份：2026 发表杂志：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

                            
                            Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan
                        

产品名称：Shh-CreERT2;Atg7-Flox;Egln1-flox

研究领域：低氧;自噬性降解;细胞衰老;衰老干预

发表年份：2026 发表杂志：Nature Aging

                            
                            A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production
                        

产品名称：S100A8-Cre;Ly6G-2A-DTRGFP

研究领域：中性粒细胞;CKLF1-PKM2轴;糖酵解;促炎性活性氧;固有免疫代谢

发表年份：2026 发表杂志：CELL DEATH AND DIFFERENTIATION

                            
                            Mechanism-Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
                        

产品名称：C57BL/6

研究领域：溶瘤肽;癌症免疫治疗;肽发现;计算生物学

发表年份：2026 发表杂志：Advanced Science

                            
                            CXCL16-driven CD4+ T cells orchestrate immunosurveillance against MHC-I-deficient hepatocellular tumors
                        

产品名称：C57BL/6

研究领域：肝细胞癌;免疫监视;MHC-I缺陷;肿瘤免疫逃逸

发表年份：2026 发表杂志：Journal for ImmunoTherapy of Cancer

                            
                            Non-competing Trop2 nanobody-based radiotheranostics for precision imaging and therapy of pancreatic cancer
                        

产品名称：M-NSG

研究领域：胰腺癌;纳米抗体;精准成像;靶向放疗

发表年份：2026 发表杂志：Materials Today Bio

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CircCDK6 Regulates Stemness Maintenance and Cisplatin Resistance in Lung Adenocarcinoma via the Wnt/β-Catenin Signaling Pathway

Liver-originated selective autophagy of BTD by alectinib underlies concurrent hepatotoxicity and dermatotoxicity

ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression

Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis

Genetic tools for targeting neuroendocrine cells: Unveiling their plasticity in lung regeneration

Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan

A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production

Mechanism-Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

CXCL16-driven CD4+ T cells orchestrate immunosurveillance against MHC-I-deficient hepatocellular tumors

Non-competing Trop2 nanobody-based radiotheranostics for precision imaging and therapy of pancreatic cancer

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