其他炎症/自免疾病模型

疾病简介

免疫介导的炎症性疾病 (immune-mediated inflammatory diseases,IMID)是一类由先天性和适应性免疫系统功能失调触发或导致失调的疾病的通称。这类疾病可能累及多种器官系统,并且伴有高发病率,生活质量下降以及过早死亡等问题。

疾病模型

为了更好进行疾病表征、靶点的鉴定以及治疗药物和治疗方法的体内评估,药物开发中往往需要合适的动物模型。南模生物炎症/自身免疫疾病评价平台拥有经验丰富的研究团队,已开发出多种 IMID 疾病小鼠模型,可根据客户需求提供个性化的药效评价服务。


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Fig 1. Type 1 diabetes mellitus model was established by intraperitoneal injection of STZ into M-NSG mice. 

The results showed that after STZ induction, the model group exhibited elevated blood glucose levels and decreased body weight.

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Fig 2. Efficacy evaluation of the type 1 diabetes mellitus model in M-NSG mice.

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Fig 1. Type 1 diabetes mellitus model was established in M-SRG rats via intraperitoneal STZ injection. 

After STZ induction, the model group exhibited hyperglycemia and reduced body weight.image.png

Fig 2. Efficacy evaluation of the type 1 diabetes mellitus model in M-SRG rats. 

The results showed significant improvements in both blood glucose levels and body weight in the treatment group.

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Fig.1 Caerulein induced chronic pancreatitis model. (A) Body Weight. (B) Body Weight Chang(%).

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Fig.2 Caerulein induced chronic pancreatitis model. (A) photos of pancreas. (B) Relative pancreas weight (mg/g).

The size and weight of pancreas were significantly decreased in caerulein treated  mice.

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Fig.3 Caerulein induced chronic pancreatitis model. 

Obvious atrophy of acinar cells can be observed in caerulein treated mice.

Significant fibrosis was observed in the pancreatic tissue of caerulein treated  mice.

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