hC3
品系全名
C57BL/6Smoc-C3em1(hC3)/Smoc
目录号
NM-HU-2000079
品系状态
活体
基因信息
基因名
C3
品系描述
通过同源重组,将小鼠C3基因进行人源化修饰。
验证数据
Fig1. Detection of C3 expression in liver by RT-PCR.
Wild type: only one band at 359 bp with primers F1/R1(mC3);Heterozygous: one band at 359 bp with primers F1/R1(mC3) and one band at 357 bp with primers F2/R2(hC3);
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hC3 expression in serum by ELISA.
Abbr. Het, heterozygous; WT, wild type. Note: Data from the collaborator.
Fig3. Detection of hC3 expression in serum by ELISA.
Note: The human Complement C3 ELISA Kit (ab108823) specifically recognized humanized C3.
Abbr. HO, homozygous; WT, wild type.
Fig4. The C3hu/hu mice showed inflammation in the portal region and bile duct hyperplasia (100× and 400×).
Fig5. The C3hu/hu mice showed glomerular sclerosis, glomerular atrophy and inflammation of the capillary tufts area (100× and 400×).
Fig6. Body Weight of C3hu/hu mice (n=12/group).
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
Fig7. Survival curve of C3hu/hu mouse (n=12/group).
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
Fig8. Serum Biochemistry of C3hu/hu mice (n=5/group).
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
Fig9. Serum Biochemistry of C3hu/hu mice (n=5/group, a different biochemical analyzer was used than in Fig8).
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
Fig10. Urinalysis of C3hu/hu mice.
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.
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